| ncRNA name | XBP1 siRNA |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | ERG, immunohistochemisty, siRNA transfection, adenoviruses transduction, Annexin V-FiTC and TUNEL assay apoptosis assay, qRT-PCR, Western blot |
| Expression pattern | associated |
| Functional description | XBP1 is an important gene involved in regulation of the anti-oxidant defense in the RPE. Knockdown of XBP1 by siRNA resulted in reduced expression of SOD1, SOD2, catalase, and glutathione synthase and sensitized RPE cells to oxidative damage. |
| PubMed ID | 22715395 |
| Year | 2012 |
| Title | X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium. |
| Drug-related ncRNA | NO |
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